In molecular biology, platelet-derived growth factor (PDGF) is one of the numerous growth factors, or proteins that regulate cell growth and division. In particular, it plays a significant role in blood vessel formation (angiogenesis), the growth of blood vessels from already-existing blood vessel tissue. Uncontrolled angiogenesis is a characteris...
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http://en.wikipedia.org/wiki/Platelet-derived_growth_factor
A family of molecules released from platelets (tiny pieces of cells that are found in the blood and that help the blood clot). Forms of platelet-derived growth factor help to heal wounds and to repair damage to blood vessel walls. They also help blood vessels grow. Also called PDGF.
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http://www.cancer.gov/dictionary?expand=P
<growth factor> The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (~30,000 D) linked by disulphide bonds. Believed to play a role in wound healing. ... It is carried in the alpha-granules of platelets and is released when platelets adhere to tr...
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http://www.encyclo.co.uk/local/20973
a substance contained in platelets and capable of inducing proliferation of vascular endothelial cells, vascular smooth muscle cells, fibroblasts, and glial cells; its action contributes to the repair of damaged vascular walls.
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(= PDGF) The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (~30,000 D) linked by disulphide bonds. Believed to play a role in wound healing. The B chain is almost identical in sequence to p28sis, the transforming protein of simian sarcoma virus, that can transform only those cells that express receptors for PDGF, suggesting that transformation is caused by autocrine stimulation. Receptor is a tyrosine kinase.
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(PDGF) Type: Term Definitions: 1. a factor in platelets that is mitogenic for cells at the site of a wound, causing endothelial proliferation; cationic glycoprotein mitogen for fibroblasts, smooth muscle cells, and glial cells. Principal factor in serum required for the growth and proliferation of mesenchymal-derived cells in tis...
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